Senior Research Associate

Description:

We are currently seeking a self-motivated Senior Research Associate to join the mouse immunization team for our therapeutic antibody discovery program. The successful candidate will play a crucial role in the early stages of antibody drug discovery, specializing in mouse colony management and executing mouse immunization strategies to generate antibodies against novel therapeutic targets.

Site: Toronto, Ontario, Canada

Key Responsibilities

• Immunization strategy development: Assist in designing immunization strategies based on target biology, antigen format, and project goals. Design and optimization of mouse immunization protocols, including adjuvant selection and in vivo immunization procedures, to generate robust immune responses against complex targets.
• Conduct routine immunization procedures in small rodents with high efficiency: Prepare antigens and adjuvants; conduct animal handling and various injection routes (SC, ID, IM, IP, IV); monitor animal health and immune responses in accordance with established protocols and ethical guidelines; collect blood samples via multiple routes; harvest lymphoid tissues (spleen, lymph nodes, and other lymphoid organs); and isolate immune cells using sterile and aseptic techniques. Coordinate shipment of biological samples to internal company sites when required.
• Mouse colony management: Work with the team members and vivarium staff to maintain and expand the company's mouse colonies, including breeding strategy design, colony management, genotyping, and data tracking and documentation.

· Laboratory maintenance: Maintain accurate experimental records and ensure data integrity. Manage laboratory inventory, equipment, and daily operations. Ensure all procedures comply with SOPs and institutional safety and animal care regulations.

Qualifications

·        M.S. or B.S. in Immunology, Cell Biology, Biology, or a related discipline, with at least 3 to 5 years of experience in a biotech or pharmaceutical R&D environment.

·        Strong proficiency in rodent handling and in vivo techniques, particularly blood and tissue collection and multiple injection routes. Hands-on experience in transgenic mouse colony management, breeding, and genotyping.

·        Hands-on experience with cell culture and primary cell isolation from rodent tissues.

·        Highly detail-oriented with a strong ability to generate accurate, reliable, and reproducible experimental results.

·        Strong team player with excellent written and verbal communication skills, as well as strong documentation and organizational abilities